Kin-Driver: a database of driver mutations in protein kinases

  title={Kin-Driver: a database of driver mutations in protein kinases},
  author={Franco L. Simonetti and Cristian Tornador and Nuria Nabau-Moret{\'o} and Miguel A. Molina-Vila and Cristina Marino Buslje},
Somatic mutations in protein kinases (PKs) are frequent driver events in many human tumors, while germ-line mutations are associated with hereditary diseases. Here we present Kin-driver, the first database that compiles driver mutations in PKs with experimental evidence demonstrating their functional role. Kin-driver is a manual expert-curated database that pays special attention to activating mutations (AMs) and can serve as a validation set to develop new generation tools focused on the… CONTINUE READING
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