Killing of trypanosomes by the human haptoglobin-related protein.

@article{Smith1995KillingOT,
  title={Killing of trypanosomes by the human haptoglobin-related protein.},
  author={A. B. Iii Smith and Jeffrey D. Esko and Stephen L. Hajduk},
  journal={Science},
  year={1995},
  volume={268 5208},
  pages={
          284-6
        }
}
African trypanosomes cause disease in humans and animals. Trypanosoma brucei brucei affects cattle but not humans because of its sensitivity to a subclass of human high density lipoproteins (HDLs) called trypanosome lytic factor (TLF). TLF contains two apolipoproteins that are sufficient to cause lysis of T. b. brucei in vitro. These proteins were identified as the human haptoglobin-related protein and paraoxonase-arylesterase. An antibody to haptoglobin inhibited TLF activity. TLF was shown to… 
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The trypanolytic factor-mechanism, impacts and applications.
Activity of human trypanosome lytic factor in mice.
An investigation into the mechanism of trypanosome lysis by human serum factors.
Hemoglobin Is a Co-Factor of Human Trypanosome Lytic Factor
TLDR
It is proposed that infection of humans by T. b.
The trypanolytic factor of human serum
TLDR
It is argued that apolipoprotein L1 is the factor that is responsible for the trypanolytic activity of human serum and this results in sleeping sickness in East Africa and West Africa.
Activity of trypanosome lytic factor: a novel component of innate immunity.
TLDR
In light of recent data, which demonstrate that TLFs can ameliorate infection by the intracellular pathogen Leishmania, the broader function of TLFs as components of innate immunity is discussed.
The lysis of Trypanosoma brucei brucei by human serum
TLDR
Current research aimed at understanding the mechamisms of cytotoxicity and the affected metabolic pathways may open new approaches for the development of specific drugs and vaccines against trypanosomiasis.
Mechanism of resistance of African trypanosomes to cytotoxic human HDL
TLDR
It is concluded that one mechanism of resistance of human sleeping-sickness trypanosomes to human serum is decreased internalization of receptor-bound TLF.
Haptoglobin-related Protein Mediates Trypanosome Lytic Factor Binding to Trypanosomes*
TLDR
Low temperature binding studies reveal two receptors for TLF-1: one that is high affinity/low capacity and another that binds with low affinity/high capacity, and it is proposed that Hpr mediates the high affinity binding of TLf-1 toT.
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References

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