Killing of leukemic cells with a BCR/ABL fusion gene by RNA interference (RNAi)

Abstract

Short 21-mer double-stranded RNA (dsRNA) molecules have recently been employed for the sequence-specific silencing of endogenous human genes. This mechanism, called RNA interference (RNAi), is extremely potent and requires only a few dsRNA molecules per cell to silence homologous gene mRNA expression. We used dsRNA targeting the M-BCR/ABL fusion site to… (More)
DOI: 10.1038/sj.onc.1205653

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