Killing of laminin receptor-positive human lung cancers by tumor infiltrating lymphocytes bearing gammadelta(+) t-cell receptors.

@article{Ferrarini1996KillingOL,
  title={Killing of laminin receptor-positive human lung cancers by tumor infiltrating lymphocytes bearing gammadelta(+) t-cell receptors.},
  author={Marina Ferrarini and Silvia Heltai and Serenella M Pupa and S Mernard and R Zocchi},
  journal={Journal of the National Cancer Institute},
  year={1996},
  volume={88 7},
  pages={436-41}
}
BACKGROUND The monomeric laminin receptor, a 67-kd high-affinity laminin-binding protein, is expressed by a variety of normal cell types. Overexpression and abnormal surface distribution of this receptor have been demonstrated in tumor cells where it appears to promote tumor invasion and metastasis. Previously, we reported the existence of an association between laminin receptor overexpression by lung cancer cells and the presence of tumor-infiltrating lymphocytes (TILs) bearing gammadelta T… CONTINUE READING

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Gammadalta TILs and chibeta+ TILs derived from four tumors were each examined for cytotoxic activity toward lung cancer target cells by use of a standard 51Cr - release assay and lung tumor cell lines expressing different levels of surface monomeric laminin receptor .
Gammadalta TILs and chibeta+ TILs derived from four tumors were each examined for cytotoxic activity toward lung cancer target cells by use of a standard 51Cr - release assay and lung tumor cell lines expressing different levels of surface monomeric laminin receptor .
Gammadalta TILs and chibeta+ TILs derived from four tumors were each examined for cytotoxic activity toward lung cancer target cells by use of a standard 51Cr - release assay and lung tumor cell lines expressing different levels of surface monomeric laminin receptor .
Previously , we reported the existence of an association between laminin receptor overexpression by lung cancer cells and the presence of tumor - infiltrating lymphocytes ( TILs ) bearing gammadelta T - cell receptors .
Killing of laminin receptor - positive human lung cancers by tumor infiltrating lymphocytes bearing gammadelta(+ ) t - cell receptors .
Previously , we reported the existence of an association between laminin receptor overexpression by lung cancer cells and the presence of tumor - infiltrating lymphocytes ( TILs ) bearing gammadelta T - cell receptors .
Killing of laminin receptor - positive human lung cancers by tumor infiltrating lymphocytes bearing gammadelta(+ ) t - cell receptors .
Gammadalta TILs and chibeta+ TILs derived from four tumors were each examined for cytotoxic activity toward lung cancer target cells by use of a standard 51Cr - release assay and lung tumor cell lines expressing different levels of surface monomeric laminin receptor .
Tumor cells from 11 lung cancer specimens exhibiting sizable gammadelta(+ ) T - cell infiltrates and from 11 other specimens infiltrated predominantly by lymphocytes bearing alphabeta(+ ) T - cell receptors were analyzed for expression of the monomeric laminin receptor by use of the monoclonal antibody ( MAb ) MLuC5 .
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