Killing of human tumor cells in culture with adriamycin conjugates of human transferrin.

@article{Yeh1984KillingOH,
  title={Killing of human tumor cells in culture with adriamycin conjugates of human transferrin.},
  author={Chih Jung Yeh and W. Page Faulk},
  journal={Clinical immunology and immunopathology},
  year={1984},
  volume={32 1},
  pages={1-11}
}
Receptors for human transferrin (Trf) in high density are found on reticulocytes and syncytiotrophoblast, but most unstimulated, normal adult cells do not bind Trf. In contrast, leukemia and breast adenocarcinoma cells have been shown to manifest Trf receptors, raising the possibility that these receptors might be employed to bind cytotoxic Trf conjugates. Trf was conjugated with adriamycin (Adr) and it was shown that the conjugates are bound by Trf receptors on plasma membranes of Daudi and HL… CONTINUE READING