Killing of Streptococcus pneumoniae by capsular polysaccharide-specific polymeric IgA, complement, and phagocytes.

@article{Janoff1999KillingOS,
  title={Killing of Streptococcus pneumoniae by capsular polysaccharide-specific polymeric IgA, complement, and phagocytes.},
  author={Edward N. Janoff and Claudine E Fasching and Jan Marc Orenstein and Jeffrey B. Rubins and N L Opstad and Agustin P. Dalmasso},
  journal={The Journal of clinical investigation},
  year={1999},
  volume={104 8},
  pages={1139-47}
}
The role of IgA in the control of invasive mucosal pathogens such as Streptococcus pneumoniae is poorly understood. We demonstrate that human pneumococcal capsular polysaccharide-specific IgA initiated dose-dependent killing of S. pneumoniae with complement and phagocytes. The majority of specific IgA in serum was of the polymeric form (pIgA), and the efficiency of pIgA-initiated killing exceeded that of monomeric IgA-initiated killing. In the absence of complement, specific IgA induced minimal… CONTINUE READING

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Biological activities of IgA

M. W. Russell, M. Kilian, M. E. Lamm
P.L. Ogra et al., editors • 1999

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