Killing of Pseudomonas aeruginosa during continuous and intermittent infusion of ceftazidime in an in vitro pharmacokinetic model.

@article{Mouton1994KillingOP,
  title={Killing of Pseudomonas aeruginosa during continuous and intermittent infusion of ceftazidime in an in vitro pharmacokinetic model.},
  author={Johan W Mouton and Jan G. den Hollander},
  journal={Antimicrobial agents and chemotherapy},
  year={1994},
  volume={38 5},
  pages={931-6}
}
An in vitro pharmacokinetic model mimicking human serum drug concentrations, based on a dialyzer unit, was developed to study the efficacies of continuous infusion and intermittent administration of ceftazidime over a period of 36 h. The daily dose of ceftazidime was 300 mg/liter/24 h given either as a continuous infusion or as three bolus doses. The… CONTINUE READING