Killing of Paracoccidioides brasiliensis yeast cells by IFN-γ and TNF-α activated murine peritoneal macrophages: evidence of H2O2 and NO effector mechanisms

Abstract

Paracoccidioidomycosis is a deep mycosis, endemic in Latin America, caused by Paracoccidioides brasiliensis. Macrophage activation by cytokines is the major effector mechanism against this fungus. This work aimed at a better understanding of the interaction between yeast cells-murine peritoneal macrophages and the cytokine signals required for the effective… (More)
DOI: 10.1007/s11046-007-9046-3

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