Killing of Neisseria meningitidis by human neutrophils: implications for normal and complement-deficient individuals.

@article{Ross1987KillingON,
  title={Killing of Neisseria meningitidis by human neutrophils: implications for normal and complement-deficient individuals.},
  author={Stephen C. Ross and Philip J. Rosenthal and Hilda Berberich and Peter Densen},
  journal={The Journal of infectious diseases},
  year={1987},
  volume={155 6},
  pages={
          1266-75
        }
}
The contributions of complement-dependent phagocytosis and serum bactericidal activity (SBA) to the killing of 62 strains of meningococci were examined by using C8-depleted or pooled human serum (PHS). The complement-dependent nature of killing by neutrophils was confirmed by restoring survival to control values by using heated serum. Serogroups B and 29E, but not A, C, Y, and W135, were ingested and killed by neutrophils in C8-depleted PHS (PHS-C8Dep; 41.7% +/- 7.3% and 60.5% +/- 17.8% vs… CONTINUE READING
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