Killing of Mycobacterium avium and Mycobacterium tuberculosis by a mycobacteriophage delivered by a nonvirulent mycobacterium: a model for phage therapy of intracellular bacterial pathogens.

@article{Broxmeyer2002KillingOM,
  title={Killing of Mycobacterium avium and Mycobacterium tuberculosis by a mycobacteriophage delivered by a nonvirulent mycobacterium: a model for phage therapy of intracellular bacterial pathogens.},
  author={Lawrence Broxmeyer and Danuta Sosnowska and Elizabeth Miltner and Ofelia Chac{\'o}n and Dirk Wagner and J A McGarvey and Ra{\'u}l Gerardo Barletta and Luiz E. Bermudez},
  journal={The Journal of infectious diseases},
  year={2002},
  volume={186 8},
  pages={1155-60}
}
Mycobacterium avium causes disseminated infection in patients with acquired immune deficiency syndrome. Mycobacterium tuberculosis is a pathogen associated with the deaths of millions of people worldwide annually. Effective therapeutic regimens exist that are limited by the emergence of drug resistance and the inability of antibiotics to kill dormant organisms. The present study describes a system using Mycobacterium smegmatis, an avirulent mycobacterium, to deliver the lytic phage TM4 where… CONTINUE READING
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