Killing of Autologous B-Lineage Malignancy Using CD3 x CD19 Bispecific Monoclonal Antibody in End Stage Leukemia and Lymphoma

@article{Haagen1994KillingOA,
  title={Killing of Autologous B-Lineage Malignancy Using CD3 x CD19 Bispecific Monoclonal Antibody in End Stage Leukemia and Lymphoma},
  author={I A Haagen and Anette J. G. Geerars and Wim BM de Lau and Mike R. Clark and R J van de Griend and Bert E. J. E. G. Bast and B C de Gast},
  journal={Blood},
  year={1994},
  volume={84 2},
  pages={556-63}
}
To develop an effective tumor immunotherapy for B-lineage non-Hodgkin's lymphoma (NHL) and acute lymphoblastic leukemia (ALL), a bispecific monoclonal antibody (BsAb) has been generated with the first specificity for the CD3 epsilon-chain and the second for the CD19 antigen. Peripheral blood mononuclear cells (PBMCs) isolated from patients with NHL or ALL during remission or relapse rapidly proliferated (up to 179-fold increase) on in vitro activation combining phytohemagglutinin or CD3… CONTINUE READING

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Cancer Gene Therapy

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