Killing mechanism of Listeria monocytogenes in activated macrophages as determined by an improved assay system.

@article{Ohya1998KillingMO,
  title={Killing mechanism of Listeria monocytogenes in activated macrophages as determined by an improved assay system.},
  author={Shogen Ohya and Huabao Xiong and Yasuyuki Tanabe and Motoki Arakawa and Masao Mitsuyama},
  journal={Journal of medical microbiology},
  year={1998},
  volume={47 3},
  pages={211-5}
}
Exposure of Listeria monocytogenes to gentamicin 5 mg/L for 4 h resulted in the killing of most extracellular bacteria, but had no effect on the survival of bacteria inside macrophages. Higher concentrations of gentamicin caused a reduction in the number of intracellular bacteria. This effect was associated with cellular uptake of gentamicin, but was unaffected by activation of macrophages by interferon-gamma and lipopolysaccharide. In experiments in which exposure to gentamicin 5 mg/L for 4 h… CONTINUE READING