Killing by bactericidal antibiotics does not depend on reactive oxygen species.

  title={Killing by bactericidal antibiotics does not depend on reactive oxygen species.},
  author={Iris Keren and Yanxia Wu and Julio F Inocencio and Lawrence R Mulcahy and Kim Lewis},
  volume={339 6124},
Bactericidal antibiotics kill by modulating their respective targets. This traditional view has been challenged by studies that propose an alternative, unified mechanism of killing, whereby toxic reactive oxygen species (ROS) are produced in the presence of antibiotics. We found no correlation between an individual cell's probability of survival in the presence of antibiotic and its level of ROS. An ROS quencher, thiourea, protected cells from antibiotics present at low concentrations, but the… CONTINUE READING

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