Killing activity and rescue function of genome-wide toxin-antitoxin loci of Mycobacterium tuberculosis.

@article{Gupta2009KillingAA,
  title={Killing activity and rescue function of genome-wide toxin-antitoxin loci of Mycobacterium tuberculosis.},
  author={Amita Jain Gupta},
  journal={FEMS microbiology letters},
  year={2009},
  volume={290 1},
  pages={45-53}
}
Toxin-antitoxin (TA) loci are typically two-component systems that encode a stable toxin, which binds an essential host target leading to cell growth arrest and/or cell death, and an unstable antitoxin, which prevents the cytotoxic activity of the toxin. The ubiquitous presence of these loci in bacterial genomes, along with their demonstrated toxicity not only in the native but also in heterologous systems, has provided the possibility of their use in wide-spectrum antibacterials. Mycobacterium… CONTINUE READING

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