Killer immunoglobulin-like receptor genotype in immune-mediated bone marrow failure syndromes.

@article{Howe2005KillerIR,
  title={Killer immunoglobulin-like receptor genotype in immune-mediated bone marrow failure syndromes.},
  author={Evan C Howe and Marcin Wojciech Wlodarski and Edward J. Ball and Lisa R Rybicki and Jaroslaw Maciejewski},
  journal={Experimental hematology},
  year={2005},
  volume={33 11},
  pages={1357-62}
}
OBJECTIVE Recent reports have shown that killer immunoglobulin-like receptors (KIR) and KIR ligand (KIR-L) genotype play a role in the pathophysiology of autoimmune disorders. Certain KIR/KIR-L combinations might convey a predisposition to immune-mediated bone marrow failure. Examining the genotypic makeup of human leukocyte antigen (HLA) class I (KIR-L) and KIR in patients with hematologic disorders could offer clues to immunogenetic risk factors for these diseases. The objective of this study… CONTINUE READING