Killer cells reactive to altered-self antigens can also be alloreactive.

@article{Bevan1977KillerCR,
  title={Killer cells reactive to altered-self antigens can also be alloreactive.},
  author={Michael J. Bevan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1977},
  volume={74 5},
  pages={2094-8}
}
  • Michael J. Bevan
  • Published 1977 in
    Proceedings of the National Academy of Sciences…
Murine cytotoxic thymus-derived lymphocytes immunized against cells bearing foreign minor histocompatibility antigens are specific for the immunizing minor antigens and for their own major H-2 antigens; they do not lyse target cells that bear the correct minor antigens plus a different H-2 haplotype. These are referred to as "altered-self" or "self-plus-X" killer cells. Alloreactive killer cells are those which respond to allogeneic cells expressing a foreign (non-self) H-2 haplotype. In this… CONTINUE READING