Killer cell Ig-like receptor and leukocyte Ig-like receptor transgenic mice exhibit tissue- and cell-specific transgene expression.

@article{Belkin2003KillerCI,
  title={Killer cell Ig-like receptor and leukocyte Ig-like receptor transgenic mice exhibit tissue- and cell-specific transgene expression.},
  author={Danny Belkin and Michaela Torkar and Chiwen Chang and Roland Barten and Mauro Tolaini and Anja Haude and Rachel Allen and Michael S J Wilson and Dimitris Kioussis and John Trowsdale},
  journal={Journal of immunology},
  year={2003},
  volume={171 6},
  pages={3056-63}
}
To generate an experimental model for exploring the function, expression pattern, and developmental regulation of human Ig-like activating and inhibitory receptors, we have generated transgenic mice using two human genomic clones: 52N12 (a 150-Kb clone encompassing the leukocyte Ig-like receptor (LILR)B1 (ILT2), LILRB4 (ILT3), and LILRA1 (LIR6) genes) and 1060P11 (a 160-Kb clone that contains ten killer cell Ig-like receptor (KIR) genes). Both the KIR and LILR families are encoded within the… CONTINUE READING
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