Kidney injury is independent of endothelial HIF-1α

  title={Kidney injury is independent of endothelial HIF-1α},
  author={Joanna Kalucka and Gunnar Schley and Adela Georgescu and Bernd Klanke and Susanne R{\"o}ssler and Jasmin Baumgartl and J. W. ten Velden and Kerstin Amann and Carsten Willam and Randall S Johnson and K E Eckardt and Alexander Weidemann},
  journal={Journal of Molecular Medicine},
Hypoxia-inducible transcription factors (HIFs) control cellular adaptation to low oxygen. In the kidney, activation of HIF is beneficial during injury; however, the specific contribution of HIF-1α in renal endothelial cells (EC) remains elusive. Since EC display tissue-specific heterogeneity, we investigated how HIF-1α affects key functions of glomerular EC in vitro and its contribution to renal development and pathophysiological adaptation to acute or chronic renal injury in vivo. Loss of HIF… CONTINUE READING
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