Kidney function and lithium concentrations of rats given an injection of lithium orotate or lithium carbonate

  title={Kidney function and lithium concentrations of rats given an injection of lithium orotate or lithium carbonate},
  author={D. F. Smith and Mogens Schou},
  journal={Journal of Pharmacy and Pharmacology},
  • D. Smith, M. Schou
  • Published 1 September 1979
  • Psychology, Medicine
  • Journal of Pharmacy and Pharmacology
A recent study by Kling et al (1978) noted the finding of higher lithium concentrations in serum and brain of rats after an intraperitoneal injection (2 mmol lithium kg−1) of lithium orotate as a slurry than of lithium carbonate in solution. The authors suggested that lithium orotate might offer advantages in the treatment of patients. We repeated the experiments of Kling et al but in addition examined the kidney function of the rats. Glomerular filtration rate and urine flow were markedly… 
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  • D. Smith
  • Psychology, Materials Science
  • 1976
1 The pharmacokinetics of the lithium ion administered as lithium orotate were studied in rats. Parallel studies were carried out with lithium carbonate and lithium chloride. 2 No differences in the
Rat brain and serum lithium concentrations after acute injections of lithium carbonate and orotate
The possibility that lower doses of lithium orotate than lithium carbonate may achieve therapeutic brain lithium concentrations and relatively stable serum concentrations is suggested.
Carl Petersens Fund and The Danish Medical Research Council provided financial support. Lithium orotate was supplied by Nadrol-Chemie