Kidney and liver involvement in monoclonal light chain disorders.

  title={Kidney and liver involvement in monoclonal light chain disorders.},
  author={Claudio Cavallo Massimo Pozzi and Francesco Locatelli},
  journal={Seminars in nephrology},
  volume={22 4},
Monoclonal light chains (LCs) are responsible for a wide spectrum of renal and hepatic diseases, that above all include amyloid light-chain (AL) amyloidosis and light chain deposition disease (LCDD). Amyloid deposits stain for Congo red on light microscopy and have fibrillar aspect on electron microscopy, whereas deposits in LCDD are positive using monotypic LCs on immunofluorescence and have a granular aspect on electron microscopy. Sometimes fibrillar and granular deposits are observed in the… CONTINUE READING


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