Kidney Cell Tumorigenesis Counterbalancing Isoform Coactivator Modulator in Human Dual Roles for Coactivator Activator and its

Abstract

Coactivator activator (CoAA) has been reported to be a coactivator that regulates steroid receptor–mediated transcription and alternative RNA splicing. Herein, we show that CoAA is a dual-function coregulator that inhibits G1-S transition in human kidney cells and suppresses anchorageindependent growth and xenograft tumor formation. Suppression occurs in… (More)

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