Kicking against the PRCs - A Domesticated Transposase Antagonises Silencing Mediated by Polycomb Group Proteins and Is an Accessory Component of Polycomb Repressive Complex 2.

@article{Liang2015KickingAT,
  title={Kicking against the PRCs - A Domesticated Transposase Antagonises Silencing Mediated by Polycomb Group Proteins and Is an Accessory Component of Polycomb Repressive Complex 2.},
  author={Shih Chieh Liang and Ben Hartwig and Pumi Perera and Santiago Mora-Garc{\'i}a and Erica de Leau and Harry Thornton and Flavia de Lima Alves and Juri Rappsilber and Suxin Yang and Geo Velikkakam James and Korbinian Schneeberger and E Jean Finnegan and Franziska Turck and Justin Goodrich},
  journal={PLoS genetics},
  year={2015},
  volume={11 12},
  pages={e1005660}
}
The Polycomb group (PcG) and trithorax group (trxG) genes play crucial roles in development by regulating expression of homeotic and other genes controlling cell fate. Both groups catalyse modifications of chromatin, particularly histone methylation, leading to epigenetic changes that affect gene activity. The trxG antagonizes the function of PcG genes by activating PcG target genes, and consequently trxG mutants suppress PcG mutant phenotypes. We previously identified the ANTAGONIST OF LIKE… CONTINUE READING
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