KiSS-1/kisspeptins and the metabolic control of reproduction: Physiologic roles and putative physiopathological implications

@article{Castellano2009KiSS1kisspeptinsAT,
  title={KiSS-1/kisspeptins and the metabolic control of reproduction: Physiologic roles and putative physiopathological implications},
  author={Jessica M. Castellano and Juan Roa and Ra{\'u}l M Luque and Carlos Di{\'e}guez and Manuel Tena-Sempere},
  journal={Peptides},
  year={2009},
  volume={30},
  pages={139-145}
}
It is well established that reproductive function is gated by the state of energy reserves of the organism; conditions of metabolic stress and energy insufficiency being frequently coupled to disturbed reproductive maturation and/or infertility. In addition, obesity is also commonly linked to altered puberty onset and reproductive impairment. Such an impact of energy status on the reproductive axis is conveyed through a number of neuropeptide hormones and metabolic cues, whose nature and… CONTINUE READING

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