Ki67 Index, HER2 Status, and Prognosis of Patients With Luminal B Breast Cancer

@article{Cheang2009Ki67IH,
  title={Ki67 Index, HER2 Status, and Prognosis of Patients With Luminal B Breast Cancer},
  author={Maggie Chon U. Cheang and Stephen Chia and David K. Voduc and Dongxia Gao and Samuel Leung and Jacqueline E. Snider and Mark Watson and Sherri R Davies and Philip S. Bernard and Joel S. Parker and Charles M. Perou and Matthew J. Ellis and Torsten O. Nielsen},
  journal={JNCI Journal of the National Cancer Institute},
  year={2009},
  volume={101},
  pages={736 - 750}
}
BACKGROUND Gene expression profiling of breast cancer has identified two biologically distinct estrogen receptor (ER)-positive subtypes of breast cancer: luminal A and luminal B. Luminal B tumors have higher proliferation and poorer prognosis than luminal A tumors. In this study, we developed a clinically practical immunohistochemistry assay to distinguish luminal B from luminal A tumors and investigated its ability to separate tumors according to breast cancer recurrence-free and disease… CONTINUE READING
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