Ki67 Index, HER2 Status, and Prognosis of Patients With Luminal B Breast Cancer

  title={Ki67 Index, HER2 Status, and Prognosis of Patients With Luminal B Breast Cancer},
  author={Maggie Chon U. Cheang and Stephen Chia and David K. Voduc and Dongxia Gao and Samuel Leung and Jacqueline E. Snider and Mark Watson and Sherri R Davies and Philip S. Bernard and Joel S. Parker and Charles M. Perou and Matthew J. Ellis and Torsten O. Nielsen},
  journal={JNCI Journal of the National Cancer Institute},
  pages={736 - 750}
BACKGROUND Gene expression profiling of breast cancer has identified two biologically distinct estrogen receptor (ER)-positive subtypes of breast cancer: luminal A and luminal B. Luminal B tumors have higher proliferation and poorer prognosis than luminal A tumors. In this study, we developed a clinically practical immunohistochemistry assay to distinguish luminal B from luminal A tumors and investigated its ability to separate tumors according to breast cancer recurrence-free and disease… CONTINUE READING
Highly Influential
This paper has highly influenced 56 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 814 extracted citations

Interlaboratory variability of Ki67 staining in breast cancer.

European journal of cancer • 2017
View 7 Excerpts
Highly Influenced

Traditional breast cancer risk factors in relation to molecular subtypes of breast cancer

Breast Cancer Research and Treatment • 2011
View 7 Excerpts
Highly Influenced

Bioinformatics and Biomedical Engineering

Lecture Notes in Computer Science • 2018
View 9 Excerpts
Highly Influenced

Managing BRCA Mutation Carriers

Springer International Publishing • 2017
View 10 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 53 references

Controversies in the assessment of HER-2: more questions than answers

TY Leong
Adv Anat Pathol • 2006
View 4 Excerpts
Highly Influenced

Supervised risk predictor of breast cancer based on intrinsic subtypes.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 2009

GATA-3 expression in breast cancer has a strong association with estrogen receptor but lacks independent prognostic value.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology • 2008

Gene expression profi ling of breast cancer

MH Galea, RW Blamey, CE Elston, IO Ellis
Annu Rev Pathol • 2008

Predictive value of tumor Ki - 67 expression in two randomized trials of adjuvant chemoendocrine therapy for node - negative breast cancer

S Liu, SK Chia, E Mehl
J Natl Cancer Inst • 2008

cancer : a systematic review and meta - analysis of 85 studies in 32 , 825 patients

AA Keshgegian, A Cnaan

Prognostic value of Ki 67 expression after short - term presurgical endocrine therapy for primary breast cancer

J Natl Cancer Inst • 2007

Similar Papers

Loading similar papers…