Ki67, PCNA, and MCM proteins: Markers of proliferation in the diagnosis of breast cancer.

@article{Jurkov2016Ki67PA,
  title={Ki67, PCNA, and MCM proteins: Markers of proliferation in the diagnosis of breast cancer.},
  author={Miroslava Jur{\'i}kov{\'a} and Ľudov{\'i}t Danihel and {\vS}tefan Pol{\'a}k and Ivan Varga},
  journal={Acta histochemica},
  year={2016},
  volume={118 5},
  pages={544-52}
}
The proliferative activity of tumour cells represents an important prognostic marker in the diagnosis of cancer. One of the methods for assessing the proliferative activity of cells is the immunohistochemical detection of cell cycle-specific antigens. For example, Ki67, proliferating cell nuclear antigen (PCNA), and minichromosome maintenance (MCM) proteins are standard markers of proliferation that are commonly used to assess the growth fraction of a cell population. The function of Ki67, the… CONTINUE READING
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