Ki-ras mutations as a prognostic factor in extrahepatic bile system cancer. PANK-ras I Project Investigators.

@article{Malats1995KirasMA,
  title={Ki-ras mutations as a prognostic factor in extrahepatic bile system cancer. PANK-ras I Project Investigators.},
  author={N{\'u}ria Malats and Miquel Porta and Josep Llu{\'i}s Pi{\~n}ol and Josep Mar{\'i}a Corominas and Juli Rif{\'a} and Francisco X Real},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={1995},
  volume={13 7},
  pages={1679-86}
}
PURPOSE To assess the prevalence and prognostic significance of Ki-ras codon 12 mutations in extrahepatic biliary system cancer (EBSC). PATIENTS AND METHODS Patients diagnosed with EBSC between 1980 and 1990 (N = 111) were selected from two hospitals. DNA was amplified from paraffin-embedded tissues and mutations in codon 12 of Ki-ras were detected using the artificial restriction fragment-length polymorphism (RFLP) technique. RESULTS Tissue was available from 68.5% of patients. The… CONTINUE READING