[Ki-67 -- new faces of an old player].


The Ki-67 protein was isolated twenty-five years ago and has become the first histological marker of proliferating cells until now. This molecule with a unique structure possesses such fundamental biological functions that are essential for normal cell proliferation. Since the Ki-67 protein is present in every dividing cell (G1, S, G2/M phase) but is absent from the resting cells (G0 phase) it is very much suitable for identifying the proliferating fraction of cells. Thus, it provides essential information concerning the malignancy of a tumor and about the prediction of response to a certain therapy. Based on its important role in cell proliferation, the Ki-67 protein might also play a role in tumor genesis. In their present work the authors discuss the history and the properties of Ki-67, its role in cell cycle regulation and its prognostic importance in different malignant disorders.

DOI: 10.1556/OH.2009.28638

Cite this paper

@article{Bubn2009Ki67N, title={[Ki-67 -- new faces of an old player].}, author={Tam{\'a}s Bub{\'a}n and L. Toth and Mikl{\'o}s Tanyi and J{\'a}nos Kappelmayer and P{\'e}ter Antal-Szalm{\'a}s}, journal={Orvosi hetilap}, year={2009}, volume={150 23}, pages={1059-70} }