Ki-67 expression in breast carcinoma: its association with grading systems, clinical parameters, and other prognostic factors--a surrogate marker?

@article{Trihia2003Ki67EI,
  title={Ki-67 expression in breast carcinoma: its association with grading systems, clinical parameters, and other prognostic factors--a surrogate marker?},
  author={Helen Trihia and Susan K Murray and Karen Price and Richard D. Gelber and Rastko Golouh and Aron Goldhirsch and Alan S. Coates and John Chibunkem Collins and Monica Castiglione-Gertsch and Barry Gusterson},
  journal={Cancer},
  year={2003},
  volume={97 5},
  pages={1321-31}
}
BACKGROUND The number of mitoses and, thus, the proliferative capacity of a tumor is one of the most crucial variables for tumor grading. The Ki-67 nuclear antigen may be considered as an alternative to mitotic counts in grading schemes and as a single parameter that can be used in fine-needle aspirates and small biopsies. METHODS Immunohistochemistry using the anti-Ki-67 antibody MIB-1 was performed on 434 breast carcinoma specimens from the International Breast Cancer Study Group (formerly… CONTINUE READING