Ki-67 expression and BrdUrd incorporation as markers of proliferative activity in human prostate tumour models.

@article{Weerden1993Ki67EA,
  title={Ki-67 expression and BrdUrd incorporation as markers of proliferative activity in human prostate tumour models.},
  author={Wytske M van Weerden and Ellis P. C. M. Moerings and A van Kreuningen and Frank H. de Jong and Gert Jan van Steenbrugge and Fritz H. Schroeder},
  journal={Cell proliferation},
  year={1993},
  volume={26 1},
  pages={67-75}
}
The validity of the use of the monoclonal antibodies Ki-67 and anti-BrdUrd to evaluate proliferative activity of human prostate tumour models was studied. Growth of the transplantable PC-82 and PC-EW prostate tumours, as assessed by tumour volume measurements, was significantly correlated with the proliferative activity as reflected by BrdUrd incorporation into DNA (r = 0.64 and r = 0.78, respectively). The proliferative activity of PC-82 tumours detected by Ki-67 antigen expression paralleled… CONTINUE READING

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