Ki-67 detects a nuclear matrix-associated proliferation-related antigen. I. Intracellular localization during interphase.

@article{Verheijen1989Ki67DA,
  title={Ki-67 detects a nuclear matrix-associated proliferation-related antigen. I. Intracellular localization during interphase.},
  author={Ren{\'e} H. M. Verheijen and Helma J. H. Kuijpers and Reinier Otto Schlingemann and Annemie L M Boehmer and Roel van Driel and G. J. Brakenhoff and Frans Charles Servatius Ramaekers},
  journal={Journal of cell science},
  year={1989},
  volume={92 ( Pt 1)},
  pages={123-30}
}
Ki-67 is a commercially available mouse monoclonal antibody, which reacts with a nuclear antigen in proliferating cells. The antibody can be used to determine the growth fraction of human tumours in situ and has been shown to be of prognostic importance. In this study it is shown that in interphase cells Ki-67 reacts with an antigen, mainly present in the nucleoli. Confocal scanning laser microscopy and immunoelectron microscopy on human MR65 monolayer cells revealed that this nucleolar antigen… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 62 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 27 references

Distribution of the 70K Ul RNAassociated protein during interphase and mitosis

  • R. VERHEUEN, H. KUUPERS, P. VOOUS, W. VAN VENROOU, F. RAMAEKERS
  • J. Cell Sci
  • 1986

Expression of a cell-cycle-associated nuclear antigen (Ki-67) in cutaneous lymphoid infiltrates

  • G. LANGE WANTZIN, D. Y. MASON
  • Am. J. Dermatopath
  • 1986

Similar Papers

Loading similar papers…