Ki-67 and PCNA Expression in Canine Mammary Tumors and Adjacent Nonneoplastic Mammary Glands: Prognostic Impact by a Multivariate Survival Analysis.

@article{Carvalho2016Ki67AP,
  title={Ki-67 and PCNA Expression in Canine Mammary Tumors and Adjacent Nonneoplastic Mammary Glands: Prognostic Impact by a Multivariate Survival Analysis.},
  author={Maria Isabel Carvalho and Isabel Pires and Justina Prada and Lu{\'i}s A Lobo and Felisbina L Queiroga},
  journal={Veterinary pathology},
  year={2016},
  volume={53 6},
  pages={1138-1146}
}
The assessment of tumor proliferation has been considered a determining prognostic factor in canine mammary tumors (CMTs). However, no studies have assessed the prognostic importance of proliferation in adjacent nonneoplastic mammary glands. We included 64 CMTs (21 benign and 43 malignant) and studied the proliferation index (PI) of Ki-67 and proliferating cell nuclear antigen (PCNA) together with several clinicopathological characteristics. A positive and statistically significant correlation… CONTINUE READING
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