Ki-67 Index Measurement in Breast Cancer Using Digital Image Analysis

  title={Ki-67 Index Measurement in Breast Cancer Using Digital Image Analysis},
  author={Hsiang-Wei Huang and Wenzhen Huang and H. H. Tsai},
Ki-67 is a nuclear protein that can be produced during cell proliferation. The Ki67 index is a valuable prognostic variable in several kinds of cancer. In breast cancer, the index is even routinely checked in many patients. Currently, pathologists use the immunohistochemistry method to calculate the percentage of Ki-67 positive malignant cells as Ki-67 index. The higher score usually means more aggressive tumor behavior. In clinical practice, the measurement of Ki-67 index relies on visual… 

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