Ki‐67 protein is associated with ribosomal RNA transcription in quiescent and proliferating cells

@article{Bullwinkel2006Ki67PI,
  title={Ki‐67 protein is associated with ribosomal RNA transcription in quiescent and proliferating cells},
  author={J. Bullwinkel and B. Baron-Luehr and Anja L{\"u}demann and C. Wohlenberg and J. Gerdes and T. Scholzen},
  journal={Journal of Cellular Physiology},
  year={2006},
  volume={206}
}
The nuclear Ki‐67 protein (pKi‐67) has previously been shown to be exclusively expressed in proliferating cells. As a result, antibodies against this protein are widely used as prognostic tools in cancer diagnostics. Here we show, that despite the strong downregulation of pKi‐67 expression in non‐proliferating cells, the protein can nevertheless be detected at sites linked to ribosomal RNA (rRNA) synthesis. Although this finding does not argue against the use of pKi‐67 as a proliferation marker… Expand
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