Khat consumption: a pharmacological review.

@article{Nencini1989KhatCA,
  title={Khat consumption: a pharmacological review.},
  author={P. Nencini and A. M. Ahmed},
  journal={Drug and alcohol dependence},
  year={1989},
  volume={23 1},
  pages={
          19-29
        }
}
The present review deals with the considerable body of evidence gathered in the last ten years on the clinical and experimental pharmacology of Khat. Khat effects are generally agreed to be of amphetamine-like type. In particular, Khat ingestion, like amphetamine ingestion, produces sympathetic activation, anorexia, euphoria, increased intellectual efficiency and alertness. These effects are mainly mediated by phenylalkylamines, such as cathinone and cathine, because the pharmacological actions… Expand
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TLDR
Findings evidence the hypothesis that the effects of CATH are dopaminergically mediated, as three experiments were conducted to measure locomotor activity following central administration of Cath in rats. Expand
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References

SHOWING 1-10 OF 71 REFERENCES
Hyperthermic response to (—)‐cathinone, an alkaloid of Catha edulis (khat)
  • P. Kalix
  • Chemistry, Medicine
  • The Journal of pharmacy and pharmacology
  • 1980
Recently, a new khat alkaloid of the phenylethylamine type has been identified and the name (-)-cathinone has been proposed (UN document 1975; Schorno & Steinegger 1979). Most of the symptomsExpand
Subjective effects of khat chewing in humans.
TLDR
The subjective effects of Khat (Catha edulis) chewing were studied in 14 male somali, habitual khat users by means of the ARCI questionnaire and of visual analogue scales concerning mood and appetite to suggest also a major role of environmental factors in the expression of these actions. Expand
A comparison of the behavioral effects of l- and dl-cathinone and d-amphetamine.
The leaves of the Catha edulis plant (Khat) are chewed extensively by inhabitants of several African and Arab countries. It has been postulated that the behavioral effects of Khat are similar toExpand
Prolonged analgesia induced by cathinone. The role of stress and opioid and nonopioid mechanisms.
TLDR
It is concluded that the prolonged analgesia induced by cathinone is primarily due to an amphetamine-like activation of monoaminergic pathways, but requires the integrity of non-mu-opioid mechanisms. Expand
Tolerance develops to sympathetic effects of khat in humans.
TLDR
Comparisons of the influence of the chewing of a standard dose of khat on some physiological parameters in chronic consumers and naive subjects suggest that tolerance develops to the sympathetic effects of k hat. Expand
Effect of the alkaloid (-) cathinone on the release of radioactivity from rabbit atria prelabelled with 3H-norepinephrine.
  • P. Kalix
  • Chemistry, Medicine
  • Life sciences
  • 1983
TLDR
The results indicate that the alkaloid (−) cathinone has an amphetamine-like releasing effect on noradrenergic nerve endings and they suggest that the cardiovascular symptoms observed during khat consumption are due to release of neurotransmitter from physiological storage sites. Expand
Possible involvement of amine oxidase inhibition in the sympathetic activation induced by khat (Catha edulis) chewing in humans.
The possibility that phenylalkylamines (cathinone and cathine) of khat, like amphetamines, are amine oxidase inhibitors with clinical significance is evaluated. Results show that khat chewing inducesExpand
Khat: scientific knowledge and policy issues.
  • P. Kalix
  • Medicine
  • British journal of addiction
  • 1987
TLDR
The socio-economic and health aspects of the khat habit are discussed together with the political issues that they imply. Expand
The role of opiate mechanisms in the development of tolerance to the anorectic effects of amphetamines
  • P. Nencini
  • Medicine
  • Pharmacology Biochemistry and Behavior
  • 1988
TLDR
It is suggested that opiates may both activate and inhibit feeding and that AMPH inhibits the activatory branch and works synergically with the inhibitory branch, resulting in hypersensitivity to exogenous opiates. Expand
Naloxone-reversible antinociceptive activity of cathinone, the active principle of khat, in the mouse and rat.
TLDR
The results suggest that besides catecholamines opioid neurotransmitters are involved in the analgesic effect of an amphetamine-like agent. Expand
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