Khat: pharmacological and medical aspects and its social use in Yemen

@article{AlMotarreb2002KhatPA,
  title={Khat: pharmacological and medical aspects and its social use in Yemen},
  author={Ahmed Al‐Motarreb and Kathryn Baker and Kenneth J. Broadley},
  journal={Phytotherapy Research},
  year={2002},
  volume={16}
}
Fresh leaves of the khat tree (Catha edulis Forsk.) are chewed for their euphoric properties in East Africa and parts of the Middle East, such as The Yemen. This review describes the history, cultivation and constituents of khat, and the social aspects of khat chewing in Yemen. The major pharmacologically active constituent of the fresh leaves is (−)‐S‐cathinone. The pharmacology of (−)‐S‐cathinone in the central nervous system and the peripheral effects are described. (−)‐S‐Cathinone is… Expand
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The Chemistry of Khat and Adverse Effect of Khat Chewing
The leaves of khat shrub have a stimulating effect, and the chewing of this material has been practiced for many centuries in certain areas of East Africa and Arabian Peninsula. Khat is widely… Expand
HEALTH AND SOCIO-ECONOMIC HAZARDS ASSOCIATED WITH KHAT CONSUMPTION
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  • Medicine
  • Journal of family & community medicine
  • 2008
TLDR
The purpose of this review is to describe briefly the adverse consequences of habitual chewing of Khat on health, and help educate the general public. Expand
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The first reported case of a pregnant patient who developed chest pain, tachycardia, and hypertension following khat-chewing session is presented, which is likely to be similar to those of amphetamine. Expand
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TLDR
Administration of Catha edulis extracts showed a deranged systemic capacity to handle oxidative radicals and induces cytotoxic effects in cells of liver and kidney, as well as induction of cell death in various human leukaemia cell lines and in peripheral human blood leukocytes. Expand
eview hat chewing , cardiovascular diseases and other internal medical problems : he current situation and directions for future research
The leaves of khat (Catha edulis Forsk.) are chewed as a social habit for the central stimulant action of their cathinone content. This review summarizes the prevalence of the habit worldwide, the… Expand
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The potential adverse health effects of khat, an evergreen shrub or tree found growing wild or cultivated in the east of a region extending from Southern Africa to the Arabian Peninsula, are summarized. Expand
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TLDR
The current knowledge on the adverse health effects of khat chewing on the cardiovascular system and other internal medical problems is outlined, the evidence and the limitations of the studies are assessed and the questions that future studies should address are identified. Expand
Potential health effects of daily khat leaves chewing: Study on the biochemical blood constituents changes among adults in Sana’a city, Yemen
TLDR
The present study investigated the biochemical changes associated with chewing Khat to investigate the effectiveness and specificity for these substances on kidney and liver function test in animals than humans. Expand
A review of the neuropharmacological properties of khat
  • A. Feyissa, J. Kelly
  • Medicine
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 2008
TLDR
It seems that the well investigated khat alkaloids have many features similar to amphetamines; however there is a need for a more thorough examination of khat itself in well designed in vitro, animal and human studies with a range of comparator drugs before confirming the claim that khat is a "natural amphetamine". Expand
A PRELIMINARY STUDY ON THE EFFECTS OF KHAT (Catha edulis) ON LIVER AND KIDNEY OF MICE
TLDR
Khat administration in the albino mice orally was associated with hepatic hypertrophy, hepatotoxicity and nephrotoxicity irrespective of the non-alcoholic substance it was administered with. Expand
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TLDR
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