Keypathophysiologic pathways in age-related macular disease

  title={Keypathophysiologic pathways in age-related macular disease},
  author={Felix Roth and Almut Bindewald and Frank G. Holz},
  journal={Graefe's Archive for Clinical and Experimental Ophthalmology},
To review current knowledge of key pathogenetic pathways in age-related macular disease (AMD). Experimental evidence and clinical observations are reviewed. A number of common downstream pathophysiologic pathways appear to be relevant in AMD manifestations irrespective of primary heterogeneous etiologies. These include sequelae of oxidative damage, retinal pigment epithelium (RPE) cell dysfunction with accumulation of lipofuscin and impairment of lysosomal functions, deposition of subsequently… CONTINUE READING


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Inhibition of the ATPdriven proton pump in RPE lysosomes by the major lipofuscin fluorophore A2E may contribute to the pathogenesis of age-related macular degeneration

  • M Bergmann, F Schutt, FG Holz, J Kopitz
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