KeyGenes, a Tool to Probe Tissue Differentiation Using a Human Fetal Transcriptional Atlas

@inproceedings{Roost2015KeyGenesAT,
  title={KeyGenes, a Tool to Probe Tissue Differentiation Using a Human Fetal Transcriptional Atlas},
  author={Matthias S. Roost and Liesbeth van Iperen and Yavuz Ariyurek and Henk PJ Buermans and Wibowo Arindrarto and Harsha D Devalla and Robert Passier and Christine L Mummery and Françoise Carlotti and Eelco J.P. de Koning and Erik W. van Zwet and Jelle J. Goeman and Susana M. Chuva de Sousa Lopes},
  booktitle={Stem cell reports},
  year={2015}
}
Differentiated derivatives of human pluripotent stem cells in culture are generally phenotypically immature compared to their adult counterparts. Their identity is often difficult to determine with certainty because little is known about their human fetal equivalents in vivo. Cellular identity and signaling pathways directing differentiation are usually determined by extrapolating information from either human adult tissue or model organisms, assuming conservation with humans. To resolve this… CONTINUE READING

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