Key tissue targets responsible for anthrax-toxin-induced lethality

  title={Key tissue targets responsible for anthrax-toxin-induced lethality},
  author={Shihui Liu and Yi Zhang and Mahtab Moayeri and Jie Liu and Devorah Crown and Rasem J. Fattah and Alexander Wein and Z Yu and Toren Finkel and Stephen H Leppla},
Bacillus anthracis, the causative agent of anthrax disease, is lethal owing to the actions of two exotoxins: anthrax lethal toxin (LT) and oedema toxin (ET). The key tissue targets responsible for the lethal effects of these toxins are unknown. Here we generated cell-type-specific anthrax toxin receptor capillary morphogenesis protein-2 (CMG2)-null mice and cell-type-specific CMG2-expressing mice and challenged them with the toxins. Our results show that lethality induced by LT and ET occurs… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 10 times. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 37 extracted citations

Designing inhibitors of anthrax toxin.

Expert opinion on drug discovery • 2014
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…