Key technologies for the industrial production of fumaric acid by fermentation.

@article{Xu2012KeyTF,
  title={Key technologies for the industrial production of fumaric acid by fermentation.},
  author={Qing Xu and Shuang Li and He Huang and Jianping Wen},
  journal={Biotechnology advances},
  year={2012},
  volume={30 6},
  pages={1685-96}
}
The growing concern about the safety of food and dairy additives and the increasing costs of petroleum-based chemicals have rekindled the interest in the fermentation processes for fumaric acid production. The key problems of the industrial production of microbial fumaric acid are reviewed in this paper. Various strategies, including strain improvement, morphology control, substrate choice, fermentation process and separation process, are summarized and compared, and their economical… CONTINUE READING
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