Key signaling pathways and targets in lung cancer therapy.

@article{Choong2007KeySP,
  title={Key signaling pathways and targets in lung cancer therapy.},
  author={Nicholas W W Choong and Ravi Salgia and Everett E. Vokes},
  journal={Clinical lung cancer},
  year={2007},
  volume={8 Suppl 2},
  pages={
          S52-60
        }
}
Despite the use of chemotherapy, radiation therapy, and surgery, the overall outcome for lung cancer continues to be disappointing. In order to make a difference in the treatment of lung cancer, novel therapeutics need to be developed. The molecular mechanisms of carcinogenesis in lung cancer are complex and involve multiple oncogenes, tumor suppressor genes, receptor tyrosine kinases, cytoplasmic enzymes, and tumor interstitial elements, among other cellular proteins. In this review, the… CONTINUE READING

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