Key roles of Ephs and ephrins in retinotectal topographic map formation.

@article{Scicolone2009KeyRO,
  title={Key roles of Ephs and ephrins in retinotectal topographic map formation.},
  author={Gabriel Scicolone and Ana Laura Ortalli and N{\'e}stor Gabriel Carri},
  journal={Brain research bulletin},
  year={2009},
  volume={79 5},
  pages={227-47}
}
Cellular and molecular mechanisms involved in the development of topographic ordered connections in the central nervous system (CNS) constitute a key issue in neurobiology because neural connectivities are the base of the CNS normal function. We discuss the roles of the Eph/ephrin system in the establishment of retinotopic projections onto the tectum/colliculus, the most detailed studied model of topographic mapping. The expression patterns of Ephs and ephrins in opposing gradients both in the… CONTINUE READING
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