Key role of tissue plasminogen activator in neurovascular coupling.

  title={Key role of tissue plasminogen activator in neurovascular coupling.},
  author={Laibaik Park and Eduardo F. Gallo and Josef Anrather and Gang Wang and Erin H. Norris and Justin Paul and Sidney Strickland and C Iadecola},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={105 3},
The increase in blood flow evoked by synaptic activity is essential for normal brain function and underlies functional brain imaging signals. Nitric oxide, a vasodilator released by NMDA receptor activation, is critical for the flow increase, but the factors linking NMDA receptor activity to nitric oxide-dependent hyperemia are poorly understood. Here, we show that tissue plasminogen activator (tPA), a serine protease implicated in NMDA receptor signaling, is required for the flow increase… CONTINUE READING
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