Key role of salsolinol in ethanol actions on dopamine neuronal activity of the posterior ventral tegmental area.

@article{Melis2015KeyRO,
  title={Key role of salsolinol in ethanol actions on dopamine neuronal activity of the posterior ventral tegmental area.},
  author={Miriam Melis and Ezio Carboni and Pierluigi Caboni and Elio Maria Gioachino Acquas},
  journal={Addiction biology},
  year={2015},
  volume={20 1},
  pages={
          182-93
        }
}
Ethanol excites dopamine (DA) neurons in the posterior ventral tegmental area (pVTA). This effect is responsible for ethanol's motivational properties and may contribute to alcoholism. Evidence indicates that catalase-mediated conversion of ethanol into acetaldehyde in pVTA plays a critical role in this effect. Acetaldehyde, in the presence of DA, condensates with it to generate salsolinol. Salsolinol, when administered in pVTA, excites pVTA DA cells, elicits DA transmission in nucleus… CONTINUE READING

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