Key role of phosphoinositide 3-kinase class IB in pancreatic cancer.

  title={Key role of phosphoinositide 3-kinase class IB in pancreatic cancer.},
  author={Charlotte E. Edling and Federico Selvaggi and Richard Buus and Tania Maffucci and Pierluigi di Sebastiano and Helmut Friess and Paolo Innocenti and Hemant M. Kocher and Marco Falasca},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={16 20},
PURPOSE Phosphoinositide 3-kinase (PI3K) signaling is well established as important in cancer. To date most studies have been focused on the PI3K/p110α isoform, which has been found to be mutated in several different cancers. The aim of our study was to determine which specific PI3K isoforms are involved in pancreatic ductal adenocarcinoma (PDAC) and investigate the effects of these isoforms on proliferation, survival, and induction of Akt activation in pancreatic cancer cells. EXPERIMENTAL… CONTINUE READING


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