Key role of a CCAAT element in regulating hepatitis B virus surface protein expression.

@article{Lu1995KeyRO,
  title={Key role of a CCAAT element in regulating hepatitis B virus surface protein expression.},
  author={Chuanyong Lu and Margaret Harris Chen and Jing-Hsiung James Ou and T. S. Benedict Yen},
  journal={Virology},
  year={1995},
  volume={206 2},
  pages={1155-8}
}
Two separate promoters, the upstream preS1 and the downstream S promoters, give rise to transcripts encoding three forms of the hepatitis B virus surface protein. Overproduction of large surface protein because of increased preS1 transcripts leads to a block in secretion of all forms of the surface protein and of virion particles. We show here that a CCAAT element in the S promoter not only increases the amount of S transcripts, but also decreases the amount of preS1 transcripts by up to… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

Similar Papers

Loading similar papers…