Key role for myeloid cells: Phase II results of anti‐GD2 antibody 3F8 plus granulocyte‐macrophage colony‐stimulating factor for chemoresistant osteomedullary neuroblastoma

@article{Cheung2014KeyRF,
  title={Key role for myeloid cells: Phase II results of anti‐GD2 antibody 3F8 plus granulocyte‐macrophage colony‐stimulating factor for chemoresistant osteomedullary neuroblastoma},
  author={Nai-Kong V Cheung and Irene Y Cheung and Kim Kramer and Shakeel Modak and Deborah Kuk and Neeta Pandit-Taskar and Elizabeth Chamberlain and Irina Ostrovnaya and Brian H. Kushner},
  journal={International journal of cancer},
  year={2014},
  volume={135 9},
  pages={2199-205}
}
Anti-G(D2) murine antibody 3F8 plus subcutaneously (sc) administered granulocyte-macrophage colony-stimulating factor (GM-CSF) was used against primary refractory neuroblastoma in metastatic osteomedullary sites. Large study size and long follow-up allowed assessment of prognostic factors in a multivariate analysis not reported with other anti-G(D2) antibodies. In a phase II trial, 79 patients without prior progressive disease were treated for persistent osteomedullary neuroblastoma documented… CONTINUE READING

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