Key role for intracellular K+ and protein kinases Sat4/Hal4 and Hal5 in the plasma membrane stabilization of yeast nutrient transporters.

@article{PrezValle2007KeyRF,
  title={Key role for intracellular K+ and protein kinases Sat4/Hal4 and Hal5 in the plasma membrane stabilization of yeast nutrient transporters.},
  author={Jorge P{\'e}rez-Valle and Huw W Jenkins and Stephanie Merchan and Vera Montiel and Jos{\'e} Ramos and Sukesh Sharma and Ram{\'o}n Serrano and Lynne Yenush},
  journal={Molecular and cellular biology},
  year={2007},
  volume={27 16},
  pages={5725-36}
}
K+ transport in living cells must be tightly controlled because it affects basic physiological parameters such as turgor, membrane potential, ionic strength, and pH. In yeast, the major high-affinity K+ transporter, Trk1, is inhibited by high intracellular K+ levels and positively regulated by two redundant "halotolerance" protein kinases, Sat4/Hal4 and Hal5. Here we show that these kinases are not required for Trk1 activity; rather, they stabilize the transporter at the plasma membrane under… CONTINUE READING
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