Key role for gene dosage and synaptic homeostasis in autism spectrum disorders.

  title={Key role for gene dosage and synaptic homeostasis in autism spectrum disorders.},
  author={Roberto Toro and Marina Konyukh and Richard Delorme and Claire Leblond and Pauline Chaste and Fabien Fauchereau and Mary Coleman and Marion Leboyer and Christopher Gillberg and Thomas Bourgeron},
  journal={Trends in genetics : TIG},
  volume={26 8},
Autism spectrum disorders (ASD) are characterized by impairments in reciprocal social communication, and repetitive, stereotyped verbal and non-verbal behaviors. Genetic studies have provided a relatively large number of genes that constitute a comprehensive framework to better understand this complex and heterogeneous syndrome. Based on the most robust findings, three observations can be made. First, genetic contributions to ASD are highly heterogeneous and most probably involve a combination… CONTINUE READING
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