Key role for Bak activation and Bak-Bax interaction in the apoptotic response to vinblastine.

@article{Upreti2008KeyRF,
  title={Key role for Bak activation and Bak-Bax interaction in the apoptotic response to vinblastine.},
  author={Meenakshi Upreti and Rong Chu and Elena N Galitovskaya and Sherri K Smart and Timothy C. Chambers},
  journal={Molecular cancer therapeutics},
  year={2008},
  volume={7 7},
  pages={2224-32}
}
Microtubule inhibitors such as vinblastine cause mitotic arrest and subsequent apoptosis through the intrinsic mitochondrial pathway. However, although Bcl-2 family proteins have been implicated as distal mediators, their precise role is largely unknown. In this study, we investigated the role of Bak in vinblastine-induced apoptosis. Bak was mainly monomeric in untreated KB-3 cells, and multimers corresponding to dimer, trimer, and higher oligomers were observed after vinblastine treatment. The… CONTINUE READING

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Characterization of vinblastine-induced Bcl-xL and Bcl-2 phosphorylation: evidence for a novel protein kinase and a Molecular Cancer Therapeutics 2231 Mol Cancer Ther 2008;7(7)

  • L Du, CS Lyle, TC. Chambers
  • July 2008 on April
  • 2008
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