Key motifs in EBV (Epstein-Barr virus)-encoded protein kinase for phosphorylation activity and nuclear localization.

@article{Gershburg2010KeyMI,
  title={Key motifs in EBV (Epstein-Barr virus)-encoded protein kinase for phosphorylation activity and nuclear localization.},
  author={Svetlana Gershburg and Leann Murphy and Manfred Marschall and Edward Gershburg},
  journal={The Biochemical journal},
  year={2010},
  volume={431 2},
  pages={227-35}
}
A sole EBV (Epstein-Barr virus)-encoded protein kinase (EBV-PK) (the BGLF4 gene product) plays important roles in viral infection. Although a number of targets of this protein have been identified, the kinase itself remains largely unstudied with regard to its enzymology and structure. In the present study, site-directed mutagenesis has been employed to generate mutations targeting residues involved in nuclear localization of the EBV-PK, core residues in subdomain III of the protein kinase… CONTINUE READING

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